Exploring the Dynamic Range of the Kinetic Exclusion Assay in Characterizing Antigen-Antibody Interactions

Therapeutic antibodies are often engineered or selected to have high on-target binding affinities that can be challenging to determine precisely by most biophysical methods. Here, we explore the dynamic range of the kinetic exclusion assay (KinExA) by exploiting the interactions of an anti-DKK antib...

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Detalles Bibliográficos
Autores principales: Bee, Christine, Abdiche, Yasmina N., Stone, Donna M., Collier, Sierra, Lindquist, Kevin C., Pinkerton, Alanna C., Pons, Jaume, Rajpal, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340344/
https://www.ncbi.nlm.nih.gov/pubmed/22558410
http://dx.doi.org/10.1371/journal.pone.0036261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340344/
https://www.ncbi.nlm.nih.gov/pubmed/22558410
http://dx.doi.org/10.1371/journal.pone.0036261

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