Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung

A new transgenic mouse model for global increases in the Sodium Dependent Vitamin C transporter 2 (SVCT2) has been generated. The SVCT2-Tg mouse shows increased SVCT2 mRNA levels in all organs tested and correspondingly increased ascorbic acid (ASC) levels in all organs except liver. The extent of t...

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Detalles Bibliográficos
Autores principales: Harrison, Fiona Edith, Best, Jennifer Lee, Meredith, Martha Elizabeth, Gamlin, Clare Ruth, Borza, Dorin-Bogdan, May, James Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340390/
https://www.ncbi.nlm.nih.gov/pubmed/22558179
http://dx.doi.org/10.1371/journal.pone.0035623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340390/
https://www.ncbi.nlm.nih.gov/pubmed/22558179
http://dx.doi.org/10.1371/journal.pone.0035623

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