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Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth p...

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Detalles Bibliográficos
Autores principales: Kerkhofs, Johan, Roberts, Scott J., Luyten, Frank P., Van Oosterwyck, Hans, Geris, Liesbet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340393/
https://www.ncbi.nlm.nih.gov/pubmed/22558096
http://dx.doi.org/10.1371/journal.pone.0034729