Allele Specific Locked Nucleic Acid Quantitative PCR (ASLNAqPCR): An Accurate and Cost-Effective Assay to Diagnose and Quantify KRAS and BRAF Mutation

The use of tyrosine kinase inhibitors (TKIs) requires the testing for hot spot mutations of the molecular effectors downstream the membrane-bound tyrosine kinases since their wild type status is expected for response to TKI therapy. We report a novel assay that we have called Allele Specific Locked...

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Detalles Bibliográficos
Autores principales: Morandi, Luca, de Biase, Dario, Visani, Michela, Cesari, Valentina, De Maglio, Giovanna, Pizzolitto, Stefano, Pession, Annalisa, Tallini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340405/
https://www.ncbi.nlm.nih.gov/pubmed/22558339
http://dx.doi.org/10.1371/journal.pone.0036084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340405/
https://www.ncbi.nlm.nih.gov/pubmed/22558339
http://dx.doi.org/10.1371/journal.pone.0036084

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