The Trim39 ubiquitin ligase inhibits APC/C(Cdh1)-mediated degradation of the Bax activator MOAP-1

Proapoptotic Bcl-2 family members, such as Bax, promote release of cytochrome c from mitochondria, leading to caspase activation and cell death. It was previously reported that modulator of apoptosis protein 1 (MOAP-1), an enhancer of Bax activation induced by DNA damage, is stabilized by Trim39, a...

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Detalles Bibliográficos
Autores principales: Huang, Nai-Jia, Zhang, Liguo, Tang, Wanli, Chen, Chen, Yang, Chih-Sheng, Kornbluth, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341153/
https://www.ncbi.nlm.nih.gov/pubmed/22529100
http://dx.doi.org/10.1083/jcb.201111141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341153/
https://www.ncbi.nlm.nih.gov/pubmed/22529100
http://dx.doi.org/10.1083/jcb.201111141

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