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The Trim39 ubiquitin ligase inhibits APC/C(Cdh1)-mediated degradation of the Bax activator MOAP-1
Proapoptotic Bcl-2 family members, such as Bax, promote release of cytochrome c from mitochondria, leading to caspase activation and cell death. It was previously reported that modulator of apoptosis protein 1 (MOAP-1), an enhancer of Bax activation induced by DNA damage, is stabilized by Trim39, a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341153/ https://www.ncbi.nlm.nih.gov/pubmed/22529100 http://dx.doi.org/10.1083/jcb.201111141 |