Cargando…
Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells
The primary cilium is an antenna-like organelle that modulates differentiation, sensory functions, and signal transduction. After cilia are disassembled at the G0/G1 transition, formation of cilia is strictly inhibited in proliferating cells. However, the mechanisms of this inhibition are unknown. I...
Autores principales: | Inoko, Akihito, Matsuyama, Makoto, Goto, Hidemasa, Ohmuro-Matsuyama, Yuki, Hayashi, Yuko, Enomoto, Masato, Ibi, Miho, Urano, Takeshi, Yonemura, Shigenobu, Kiyono, Tohru, Izawa, Ichiro, Inagaki, Masaki |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341160/ https://www.ncbi.nlm.nih.gov/pubmed/22529102 http://dx.doi.org/10.1083/jcb.201106101 |
Ejemplares similares
-
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway
por: Inaba, Hironori, et al.
Publicado: (2016) -
Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells
por: Matsuyama, Makoto, et al.
Publicado: (2013) -
Trichoplein keeps primary cilia silent
por: Short, Ben
Publicado: (2012) -
Cell cycle progression by the repression of primary cilia formation in proliferating cells
por: Goto, Hidemasa, et al.
Publicado: (2013) -
Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice
por: Tanaka, Hiroki, et al.
Publicado: (2015)