Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame

Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway. To develop a delNS1 virus with specific immunostimulatory properties, we used an optimised technology to insert t...

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Detalles Bibliográficos
Autores principales: van Rikxoort, Marijke, Michaelis, Martin, Wolschek, Markus, Muster, Thomas, Egorov, Andrej, Seipelt, Joachim, Doerr, Hans Wilhelm, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341362/
https://www.ncbi.nlm.nih.gov/pubmed/22563505
http://dx.doi.org/10.1371/journal.pone.0036506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341362/
https://www.ncbi.nlm.nih.gov/pubmed/22563505
http://dx.doi.org/10.1371/journal.pone.0036506

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