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New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

BACKGROUND: Deoxyribonucleic acid (DNA) topology plays a critical role in maintaining the integrity of the genome and cellular functions. Although changes in DNA conformation and structural dynamics in the brain have been associated with various neurological disorders, its precise role in the pathog...

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Detalles Bibliográficos
Autores principales: Vasudevaraju, P., Guerrero, Erika, Hegde, Muralidhar L., Collen, T. B., Britton, Gabrielle B., Rao, K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341714/
https://www.ncbi.nlm.nih.gov/pubmed/22557921
http://dx.doi.org/10.4103/0975-7406.94811