Cargando…

New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

BACKGROUND: Deoxyribonucleic acid (DNA) topology plays a critical role in maintaining the integrity of the genome and cellular functions. Although changes in DNA conformation and structural dynamics in the brain have been associated with various neurological disorders, its precise role in the pathog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasudevaraju, P., Guerrero, Erika, Hegde, Muralidhar L., Collen, T. B., Britton, Gabrielle B., Rao, K. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341714/ https://www.ncbi.nlm.nih.gov/pubmed/22557921 http://dx.doi.org/10.4103/0975-7406.94811

Ejemplares similares

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
por: Mitra, Joy, et al.
Publicado: (2014)

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
por: Castillo-Carranza, Diana L., et al.
Publicado: (2018)

Non-steric-zipper models for pathogenic α-synuclein conformers
por: Schuman, Brock, et al.
Publicado: (2018)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

α-Synuclein modulates tau spreading in mouse brains
por: Bassil, Fares, et al.
Publicado: (2020)

Neuronal identity defines α-synuclein and tau toxicity
por: Praschberger, Roman, et al.
Publicado: (2023)

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation
por: Lucas, Heather R., et al.
Publicado: (2019)

Alpha-synuclein and tau: teammates in neurodegeneration?
por: Moussaud, Simon, et al.
Publicado: (2014)

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
por: Dominguez-Meijide, Antonio, et al.
Publicado: (2020)

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau
por: Hudák, Anett, et al.
Publicado: (2019)

Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau
por: Stoyka, Lindsay E., et al.
Publicado: (2021)

GC- and AT-rich chromatin domains differ in conformation and histone modification status and are differentially modulated by Rpd3p
por: Dekker, Job
Publicado: (2007)

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level
por: Sandal, Massimo, et al.
Publicado: (2008)

Investigation of Intramolecular Dynamics and Conformations of α-, β- and γ-Synuclein
por: Ducas, Vanessa C., et al.
Publicado: (2014)

Conformational templating of α-synuclein aggregates in neuronal-glial cultures
por: Sacino, Amanda N, et al.
Publicado: (2013)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
por: Schmitz, Matthias, et al.
Publicado: (2023)

Conformational changes involved in sGC activation
por: Marletta, Michael A, et al.
Publicado: (2013)

Dopamine-Induced Conformational Changes in Alpha-Synuclein
por: Outeiro, Tiago F., et al.
Publicado: (2009)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
por: Gerson, Julia E., et al.
Publicado: (2018)

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved
por: Vasili, Eftychia, et al.
Publicado: (2019)

Interplay between tau and α‐synuclein liquid–liquid phase separation
por: Siegert, Anna, et al.
Publicado: (2021)

Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
por: Lopes, Douglas M., et al.
Publicado: (2022)

Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
por: Tarutani, Airi, et al.
Publicado: (2022)

Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology
por: Jorge-Oliva, Marta, et al.
Publicado: (2022)

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells
por: Fakhree, Mohammad A. A., et al.
Publicado: (2018)

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?
por: Hoppe, Simon Oliver, et al.
Publicado: (2021)

Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression
por: Mustak, Mohammed S., et al.
Publicado: (2010)

CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation
por: Shim, Kyu Hwan, et al.
Publicado: (2020)

Molecular biology research in neuropsychiatry: India’s contribution
por: Sathyanarayana Rao, T. S., et al.
Publicado: (2010)

Identification of GC-rich LAT genes in birds
por: Janusova, Sarka, et al.
Publicado: (2023)

Correction to: Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
por: Tarutani, Airi, et al.
Publicado: (2022)

NMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies
por: Italia, Maria, et al.
Publicado: (2022)

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons
por: Griffin, Tagan A., et al.
Publicado: (2023)

α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation
por: Bai, Jia, et al.
Publicado: (2016)

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing
por: Stephens, Amberley D., et al.
Publicado: (2018)

α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications
por: Li, Amanda, et al.
Publicado: (2022)

Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces
por: Roeters, Steven J., et al.
Publicado: (2023)

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
por: Twohig, Daniel, et al.
Publicado: (2018)

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
por: Provasek, Vincent E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jbfflo1uvk74uorh3n42ta2q93