Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy

BACKGROUND: We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody...

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Detalles Bibliográficos
Autores principales: Bellone, S, Roque, D, Cocco, E, Gasparrini, S, Bortolomai, I, Buza, N, Abu-Khalaf, M, Silasi, D-A, Ratner, E, Azodi, M, Schwartz, P E, Rutherford, T J, Pecorelli, S, Santin, A D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341945/
https://www.ncbi.nlm.nih.gov/pubmed/22531721
http://dx.doi.org/10.1038/bjc.2012.132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341945/
https://www.ncbi.nlm.nih.gov/pubmed/22531721
http://dx.doi.org/10.1038/bjc.2012.132

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