Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(−16)...

Descripción completa

Detalles Bibliográficos
Autores principales: Fradin, Delphine, Le Fur, Sophie, Mille, Clémence, Naoui, Nadia, Groves, Chris, Zelenika, Diana, McCarthy, Mark I., Lathrop, Mark, Bougnères, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342174/
https://www.ncbi.nlm.nih.gov/pubmed/22567146
http://dx.doi.org/10.1371/journal.pone.0036278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342174/
https://www.ncbi.nlm.nih.gov/pubmed/22567146
http://dx.doi.org/10.1371/journal.pone.0036278

Ejemplares similares