MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

The genome-wide association study (GWAS) approach has discovered hundreds of genetic variants associated with diseases and quantitative traits. However, despite clinical overlap and statistical correlation between many phenotypes, GWAS are generally performed one-phenotype-at-a-time. Here we compare...

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Detalles Bibliográficos
Autores principales: O’Reilly, Paul F., Hoggart, Clive J., Pomyen, Yotsawat, Calboli, Federico C. F., Elliott, Paul, Jarvelin, Marjo-Riitta, Coin, Lachlan J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342314/
https://www.ncbi.nlm.nih.gov/pubmed/22567092
http://dx.doi.org/10.1371/journal.pone.0034861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342314/
https://www.ncbi.nlm.nih.gov/pubmed/22567092
http://dx.doi.org/10.1371/journal.pone.0034861

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