Identity by Descent Mapping of Founder Mutations in Cancer Using High-Resolution Tumor SNP Data

Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Letouzé, Eric, Sow, Aliou, Petel, Fabien, Rosati, Roberto, Figueiredo, Bonald C., Burnichon, Nelly, Gimenez-Roqueplo, Anne-Paule, Lalli, Enzo, de Reyniès, Aurélien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342326/
https://www.ncbi.nlm.nih.gov/pubmed/22567117
http://dx.doi.org/10.1371/journal.pone.0035897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342326/
https://www.ncbi.nlm.nih.gov/pubmed/22567117
http://dx.doi.org/10.1371/journal.pone.0035897

Ejemplares similares