Deficiency of C-C Chemokine Receptor 5 Suppresses Tumor Development via Inactivation of NF-κB and Upregulation of IL-1Ra in Melanoma Model

To evaluate the relevance of C-C chemokine receptor type 5 (CCR5) expression and tumor development, we compared melanoma growth in CCR5 knockout (CCR5(−/−)) mice and wild type (CCR5(+/+)) mice. CCR5(−/−) mice showed reduced tumor volume, tumor weight, and increased survival rate when compared to CCR...

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Detalles Bibliográficos
Autores principales: Song, Ju Kyoung, Park, Mi Hee, Choi, Dong-Young, Yoo, Hwan Soo, Han, Sang Bae, Yoon, Do Young, Hong, Jin Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342329/
https://www.ncbi.nlm.nih.gov/pubmed/22567084
http://dx.doi.org/10.1371/journal.pone.0033747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342329/
https://www.ncbi.nlm.nih.gov/pubmed/22567084
http://dx.doi.org/10.1371/journal.pone.0033747

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