Cargando…

Deficiency of C-C Chemokine Receptor 5 Suppresses Tumor Development via Inactivation of NF-κB and Upregulation of IL-1Ra in Melanoma Model

To evaluate the relevance of C-C chemokine receptor type 5 (CCR5) expression and tumor development, we compared melanoma growth in CCR5 knockout (CCR5(−/−)) mice and wild type (CCR5(+/+)) mice. CCR5(−/−) mice showed reduced tumor volume, tumor weight, and increased survival rate when compared to CCR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Ju Kyoung, Park, Mi Hee, Choi, Dong-Young, Yoo, Hwan Soo, Han, Sang Bae, Yoon, Do Young, Hong, Jin Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342329/ https://www.ncbi.nlm.nih.gov/pubmed/22567084 http://dx.doi.org/10.1371/journal.pone.0033747

Ejemplares similares

Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma
por: Brownlie, Rebecca J., et al.
Publicado: (2023)

Desmoplastic melanoma: C>Ts and NF‐κB
por: Rabbie, Roy, et al.
Publicado: (2016)

C1-inactivator is upregulated in glioblastoma
por: Förnvik, Karolina, et al.
Publicado: (2017)

Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils
por: Haddad, Lydia E., et al.
Publicado: (2014)

Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts
por: Washio, Kohei, et al.
Publicado: (2015)

Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes
por: An, Soo Yeon, et al.
Publicado: (2017)

NF-κB Dependent Chemokine Signaling in Pancreatic Cancer
por: Geismann, Claudia, et al.
Publicado: (2019)

Resistin Stimulates Expression of Chemokine Genes in Chondrocytes via Combinatorial Regulation of C/EBPβ and NF-κB
por: Zhang, Ziji, et al.
Publicado: (2014)

An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma
por: Barbero, Gastón, et al.
Publicado: (2019)

IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
por: Hwang, Sue-Yun, et al.
Publicado: (2004)

JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma
por: Zhu, Qi, et al.
Publicado: (2022)

Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans
por: Heo, Won Il, et al.
Publicado: (2020)

Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata
por: Alghamdi, Mansour A., et al.
Publicado: (2022)

Methanol Extract of Artemisia apiacea Hance Attenuates the Expression of Inflammatory Mediators via NF-κB Inactivation
por: Ryu, Ji Choul, et al.
Publicado: (2013)

Toxoplasma gondii Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF-κB Activation
por: Kim, Ji-Young, et al.
Publicado: (2006)

Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
por: Yang, Liu, et al.
Publicado: (2015)

Corrigendum: Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans
por: Heo, Won Il, et al.
Publicado: (2020)

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation
por: Kim, Shin Young, et al.
Publicado: (2019)

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip
por: Lee, Jongeun, et al.
Publicado: (2013)

GNA13 promotes tumor growth and angiogenesis by upregulating CXC chemokines via the NF‐κB signaling pathway in colorectal cancer cells
por: Zhang, Zhongqiang, et al.
Publicado: (2018)

IL-33 Drives Monocyte Recruitment to Lung Interstitium through Chemokine Upregulation
por: Tjota, Melissa Y., et al.
Publicado: (2017)

IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
por: Oh, J H, et al.
Publicado: (2011)

Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals
por: Yun, H-M, et al.
Publicado: (2013)

Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB
por: Tourniaire, Franck, et al.
Publicado: (2013)

Non-canonical NFκB activation promotes chemokine expression in podocytes
por: Valiño-Rivas, Lara, et al.
Publicado: (2016)

Upregulated Expression of C-X-C Chemokine Receptor 4 Is an Independent Prognostic Predictor for Patients with Gastric Cancer
por: He, Hongyong, et al.
Publicado: (2013)

Fine Structures in $^{14}C$ Emission of $^{223}Ra$ and $^{224}Ra$
por: Hourani, E, et al.
Publicado: (1991)

NFκB-regulation of c-FLIP promotes TNFα-mediated RAF inhibitor resistance in melanoma
por: Shao, Yongping, et al.
Publicado: (2015)

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
por: Li, Taiwei, et al.
Publicado: (2021)

c-Myb interferes with inflammatory IL1α-NF-κB pathway in breast cancer cells
por: Dúckaa, Monik, et al.
Publicado: (2021)

Transfer and intra-articular expression of the IL-1Ra cDNA in human rheumatoid joints
por: Evans, CH, et al.
Publicado: (2001)

Ethanol promoting the upregulation of C-X-C Motif Chemokine Ligand 1（CXCL1） and C-X-C Motif Chemokine Ligand 6（CXCL6） in models of early alcoholic liver disease
por: Jiang, Yao, et al.
Publicado: (2022)

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling
por: Li, Jing, et al.
Publicado: (2016)

Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition
por: Lee, Yong Sun, et al.
Publicado: (2018)

Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1
por: Wang, Zhe, et al.
Publicado: (2018)

NF-κB activation by the viral oncoprotein StpC is enhanced by ERK-mediated p52 and RelB upregulation
por: Katsch, K, et al.
Publicado: (2009)

Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling
por: Wang, Ru, et al.
Publicado: (2023)

NF-κB as potential target in the treatment of melanoma
por: Madonna, Gabriele, et al.
Publicado: (2012)

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation
por: Kim, Jung-Hyun, et al.
Publicado: (2014)

Keratin 17 Promotes T Cell Response in Allergic Contact Dermatitis by Upregulating C–C Motif Chemokine Ligand 20
por: Luo, Yixin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_18tbgnsb3983j1q6eurv6no6ai