The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance

Negative costimulatory molecules, acting through so-called inhibitory pathways, play a crucial role in the control of T cell responses. This negative “second signal” opposes T cell receptor activation and leads to downregulation of T cell proliferation and promotes antigen specific tolerance. Much i...

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Detalles Bibliográficos
Autores principales: McGrath, Martina M., Najafian, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342378/
https://www.ncbi.nlm.nih.gov/pubmed/22566929
http://dx.doi.org/10.3389/fimmu.2012.00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342378/
https://www.ncbi.nlm.nih.gov/pubmed/22566929
http://dx.doi.org/10.3389/fimmu.2012.00047

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