Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells

Variable sensitivity to T-cell-receptor (TCR)- and IL-7-receptor (IL-7R)-mediated homeostatic signals among naïve T cells has thus far been largely attributed to differences in TCR specificity. We show here that even when withdrawn from self-peptide-induced TCR stimulation, CD8(+) T cells exhibit he...

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Detalles Bibliográficos
Autores principales: Palmer, Megan J, Mahajan, Vinay S, Chen, Jianzhu, Irvine, Darrell J, Lauffenburger, Douglas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Outstanding Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342499/
https://www.ncbi.nlm.nih.gov/pubmed/21339767
http://dx.doi.org/10.1038/icb.2011.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342499/
https://www.ncbi.nlm.nih.gov/pubmed/21339767
http://dx.doi.org/10.1038/icb.2011.5

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