Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

Triapine is an α-N-heterocyclic thiosemicarbazone with promising anticancer activity against hematologic malignancies but widely ineffective against solid tumor types in clinical trials. The anticancer activity of thiosemicarbazones can be dramatically increased by terminal dimethylation. KP1089 is...

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Detalles Bibliográficos
Autores principales: Heffeter, Petra, Pirker, Christine, Kowol, Christian R., Herrman, Gerrit, Dornetshuber, Rita, Miklos, Walter, Jungwirth, Ute, Koellensperger, Gunda, Keppler, Bernhard K., Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342514/
https://www.ncbi.nlm.nih.gov/pubmed/22426010
http://dx.doi.org/10.1016/j.bcp.2012.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342514/
https://www.ncbi.nlm.nih.gov/pubmed/22426010
http://dx.doi.org/10.1016/j.bcp.2012.03.004

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