Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

Tubulin tyrosine ligase (TTL) catalyzes the post-translational C-terminal tyrosination of α–tubulin. Tyrosination regulates recruitment of microtubule interacting proteins. TTL is essential. Its loss causes morphogenic abnormalities and is associated with cancers of poor prognosis. We present the fi...

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Detalles Bibliográficos
Autores principales: Szyk, Agnieszka, Deaconescu, Alexandra M., Piszczek, Grzegorz, Roll-Mecak, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342691/
https://www.ncbi.nlm.nih.gov/pubmed/22020298
http://dx.doi.org/10.1038/nsmb.2148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342691/
https://www.ncbi.nlm.nih.gov/pubmed/22020298
http://dx.doi.org/10.1038/nsmb.2148

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