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Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin
Tubulin tyrosine ligase (TTL) catalyzes the post-translational C-terminal tyrosination of α–tubulin. Tyrosination regulates recruitment of microtubule interacting proteins. TTL is essential. Its loss causes morphogenic abnormalities and is associated with cancers of poor prognosis. We present the fi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342691/ https://www.ncbi.nlm.nih.gov/pubmed/22020298 http://dx.doi.org/10.1038/nsmb.2148 |