A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines

BACKGROUND: PTEN is an important tumour suppressor gene that is mutated in Cowden syndrome as well as various sporadic cancers. CpG island hypermethylation is another route to tumour suppressor gene inactivation, however, the literature regarding PTEN hypermethylation in cancer is controversial. Fur...

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Detalles Bibliográficos
Autores principales: Hesson, Luke B, Packham, Deborah, Pontzer, Emily, Funchain, Pauline, Eng, Charis, Ward, Robyn L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342897/
https://www.ncbi.nlm.nih.gov/pubmed/22490388
http://dx.doi.org/10.1186/1480-9222-14-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342897/
https://www.ncbi.nlm.nih.gov/pubmed/22490388
http://dx.doi.org/10.1186/1480-9222-14-5

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