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A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
BACKGROUND: PTEN is an important tumour suppressor gene that is mutated in Cowden syndrome as well as various sporadic cancers. CpG island hypermethylation is another route to tumour suppressor gene inactivation, however, the literature regarding PTEN hypermethylation in cancer is controversial. Fur...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342897/ https://www.ncbi.nlm.nih.gov/pubmed/22490388 http://dx.doi.org/10.1186/1480-9222-14-5 |