Cargando…

Immunological Tolerance to Muscle Autoantigens Involves Peripheral Deletion of Autoreactive CD8(+) T Cells

Muscle potentially represents the most abundant source of autoantigens of the body and can be targeted by a variety of severe autoimmune diseases. Yet, the mechanisms of immunological tolerance toward muscle autoantigens remain mostly unknown. We investigated this issue in transgenic SM-Ova mice tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franck, Emilie, Bonneau, Carole, Jean, Laetitia, Henry, Jean-Paul, Lacoume, Yann, Salvetti, Anna, Boyer, Olivier, Adriouch, Sahil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343038/ https://www.ncbi.nlm.nih.gov/pubmed/22570714 http://dx.doi.org/10.1371/journal.pone.0036444

Ejemplares similares

Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer
por: Adriouch, Sahil, et al.
Publicado: (2011)

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells
por: Honke, Nadine, et al.
Publicado: (2017)

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
por: Bronge, Mattias, et al.
Publicado: (2022)

Induction of Hematopoietic Microchimerism by Gene-Modified BMT Elicits Antigen-Specific B and T Cell Unresponsiveness toward Gene Therapy Products
por: Martinet, Jérémie, et al.
Publicado: (2016)

Death, autoantigen modifications, and tolerance
por: Utz,, Paul J, et al.
Publicado: (2000)

Mechanical-Stretch of C2C12 Myoblasts Inhibits Expression of Toll-Like Receptor 3 (TLR3) and of Autoantigens Associated with Inflammatory Myopathies
por: Chen, Rong, et al.
Publicado: (2013)

Characterization of autoreactive T cells to the autoantigens hnRNP-A2/RA33 and filaggrin in patients with rheumatoid arthritis and controls
por: Fritsch, R, et al.
Publicado: (2001)

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles
por: Law, Soi Cheng, et al.
Publicado: (2012)

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
por: Kissel, Theresa, et al.
Publicado: (2022)

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
por: Pobezinsky, Leonid A., et al.
Publicado: (2012)

Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses
por: Scarpitta, Allan, et al.
Publicado: (2021)

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice
por: Zhang, Mingfeng, et al.
Publicado: (2018)

Editorial: Immunological Tolerance in Transplantation: More Than Deletion
por: Pilat, Nina, et al.
Publicado: (2022)

P2X7 on Mouse T Cells: One Channel, Many Functions
por: Rissiek, Björn, et al.
Publicado: (2015)

Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells
por: Kang, Hee-Kap, et al.
Publicado: (2009)

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity
por: Seddon, Benedict, et al.
Publicado: (1999)

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis
por: Huang, Qi-Quan, et al.
Publicado: (2015)

Controlling Autoreactivity of CD4 T Cells by Local Tolerance Induction
por: FöRster, Irmgard
Publicado: (1998)

Receptor editing: an approach by autoreactive B cells to escape tolerance
Publicado: (1993)

Generation of Pure Highly Functional Human Anti-Tumor Specific Cytotoxic T Lymphocytes With Stem Cell-Like Memory Features for Melanoma Immunotherapy
por: Hamieh, Mohamad, et al.
Publicado: (2021)

Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome
por: Chernomordik, Fernando, et al.
Publicado: (2023)

Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4(+) T cells specific for the epidermal autoantigen desmoglein 3
por: Iriki, Hisato, et al.
Publicado: (2023)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
por: Preti, Max, et al.
Publicado: (2021)

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target
por: Liu, Rongzeng, et al.
Publicado: (2022)

Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim
por: Davey, Gayle M., et al.
Publicado: (2002)

Identification of autoreactive B cells with labeled nucleosomes
por: Gies, Vincent, et al.
Publicado: (2017)

Immunogenicity of autoantigens
por: Backes, Christina, et al.
Publicado: (2011)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

Circulating autoreactive proteinase 3(+) B cells and tolerance checkpoints in ANCA-associated vasculitis
por: Berti, Alvise, et al.
Publicado: (2021)

Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens
por: Tian, Jide, et al.
Publicado: (2009)

The Peripheral Deletion of Autoreactive CD8(+) T Cells Induced by Cross-presentation of Self-antigens Involves Signaling through CD95 (Fas, Apo-1)
por: Kurts, Christian, et al.
Publicado: (1998)

The inability to process a self-peptide allows autoreactive T cells to escape tolerance
Publicado: (1993)

B Cell Receptor Signaling-Based Index as a Biomarker for the Loss of Peripheral Immune Tolerance in Autoreactive B Cells in Rheumatoid Arthritis
por: Lyubchenko, Taras, et al.
Publicado: (2014)

Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus
por: Iriki, Hisato, et al.
Publicado: (2021)

Proteinase 3 Autoreactivity in Anti‐Neutrophil Cytoplasmic Antibody–associated vasculitis—Immunological versus clinical features
por: Sharma, Ravi K., et al.
Publicado: (2020)

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
por: du Pré, M. Fleur, et al.
Publicado: (2019)

Immunological T-cell memory in the in vitro-induced experimental autoimmune orchitis: specificity of the reaction and tissue distribution of the autoantigens
Publicado: (1978)

Identification of Autoreactive B Cell Subpopulations in Peripheral Blood of Autoimmune Patients With Pemphigus Vulgaris
por: Pollmann, Robert, et al.
Publicado: (2019)

The secret autoreactivity of B cells
por: Williams, Ruth
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_l6r7fplaqe9dqv7l05m37c9vf8