RNA Interference Is Responsible for Reduction of Transgene Expression after Sleeping Beauty Transposase Mediated Somatic Integration

BACKGROUND: Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer. For the Sleeping Beauty (SB) transposase system it was demonstrated that convergent transcription driven by the S...

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Detalles Bibliográficos
Autores principales: Rauschhuber, Christina, Ehrhardt, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343047/
https://www.ncbi.nlm.nih.gov/pubmed/22570690
http://dx.doi.org/10.1371/journal.pone.0035389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343047/
https://www.ncbi.nlm.nih.gov/pubmed/22570690
http://dx.doi.org/10.1371/journal.pone.0035389

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