Cargando…

Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627

The ribonucleoprotein (RNP) complex is the essential transcription-replication machinery of the influenza virus. It is composed of the trimeric polymerase (PA, PB1 and PB2), nucleoprotein (NP) and RNA. Elucidating the molecular mechanisms of RNP assembly is central to our understanding of the contro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, Andy Ka-Leung, Chan, Wai-Hon, Choi, Sze-Ting, Lam, Mandy Ka-Han, Lau, Kwok-Fai, Chan, Paul Kay-Sheung, Au, Shannon Wing-Ngor, Fodor, Ervin, Shaw, Pang-Chui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343083/ https://www.ncbi.nlm.nih.gov/pubmed/22570712 http://dx.doi.org/10.1371/journal.pone.0036415

Ejemplares similares

Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein
por: Hsia, Ho-Pan, et al.
Publicado: (2018)

Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
por: Nilsson, Benjamin E., et al.
Publicado: (2017)

Interaction of Influenza A Nucleoprotein with Host hnRNP-C Is Implicated in Viral Replication
por: Tang, Yun-Sang, et al.
Publicado: (2022)

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein
por: Liu, Ming, et al.
Publicado: (2015)

NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes
por: Kato, Yusuke S., et al.
Publicado: (2017)

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
por: Song, Wenjun, et al.
Publicado: (2014)

The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
por: Long, Joshua C. D., et al.
Publicado: (2016)

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N
por: Steel, John, et al.
Publicado: (2009)

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7
por: Hudjetz, Ben, et al.
Publicado: (2012)

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit
por: Tarendeau, Franck, et al.
Publicado: (2008)

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase
por: Jagger, Brett W., et al.
Publicado: (2010)

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
por: Turrell, Lauren, et al.
Publicado: (2013)

Structure of an H3N2 influenza virus nucleoprotein
por: Knight, Michael L., et al.
Publicado: (2021)

Interaction between influenza A virus nucleoprotein and PB2 cap-binding domain is mediated by RNA
por: Szeto, Wun-Chung, et al.
Publicado: (2020)

The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
por: Li, Weixuan, et al.
Publicado: (2017)

Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals
por: Liang, Libin, et al.
Publicado: (2019)

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells
por: Vreede, Frank T., et al.
Publicado: (2010)

Identification of influenza A nucleoprotein as an antiviral target
por: Kao, Richard Y, et al.
Publicado: (2010)

Effect of avian influenza A H5N1 infection on the expression of microRNA-141 in human respiratory epithelial cells
por: Lam, Wai-Yip, et al.
Publicado: (2013)

Different facets of intracranial central nervous system lymphoma and its imaging mimics
por: Kwok, Hoi Ming, et al.
Publicado: (2022)

Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers
por: Tsoi, Tik-Hung, et al.
Publicado: (2016)

Awareness of meaning and quest for meaning: The mechanisms between future orientation and prosociality among youth during pandemic
por: Lui, Wai-Kin, et al.
Publicado: (2022)

A 627K variant in the PB2 protein of H9 subtype influenza virus in wild birds
por: Ge, Ye, et al.
Publicado: (2018)

A brief report on the normal range of forehead temperature as determined by noncontact, handheld, infrared thermometer
por: Ng, Daniel Kwok-keung, et al.
Publicado: (2005)

Acupuncture improves cognitive function: A systematic review☆
por: Leung, Mason Chin Pang, et al.
Publicado: (2013)

IS627: Radiotracer diﬀusion in refractory high-entropy alloys
por: Divinski, S V
Publicado: (2019)

CCNP security IPS 642-627 quick reference
por: Halleen, Gary
Publicado: (2011)

627. Tele-OPAT Outcomes at Two Community Hospitals
por: Sheridan, Kathleen R, et al.
Publicado: (2020)

Marrow tuberculosis without granuloma formation in a patient with human immunodeficiency virus infection
por: Lam, Wing Kit, et al.
Publicado: (2023)

Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery
por: Walker, Alexander P., et al.
Publicado: (2019)

The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a
por: Veler, Hana, et al.
Publicado: (2022)

RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II
por: Martínez-Alonso, Mónica, et al.
Publicado: (2016)

Dynamic PB2-E627K substitution of influenza H7N9 virus indicates the in vivo genetic tuning and rapid host adaptation
por: Liu, William J., et al.
Publicado: (2020)

Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site
por: Mak, Amanda Nga-Sze, et al.
Publicado: (2007)

The C-terminal LCAR of host ANP32 proteins interacts with the influenza A virus nucleoprotein to promote the replication of the viral RNA genome
por: Wang, Fangzheng, et al.
Publicado: (2022)

Supratentorial Intraparenchymal Haemorrhages during Spine Surgery
por: Leung, Gilberto Ka Kit, et al.
Publicado: (2014)

CCNP Security IPS 642-627: official cert guide
por: Burns, David, et al.
Publicado: (2012)

Correction to Lancet Gastroenterol Hepatol 2022; 7: 627–47
Publicado: (2022)

Acute renal impairment in coronavirus-associated severe acute respiratory syndrome
por: Chu, Kwok Hong, et al.
Publicado: (2005)

Seminal vesicle metastasis from hepatocellular carcinoma and renal cell carcinoma
por: Chan, Marius Wai-Lok, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9qtegsignc7vkbjhg2q430tm8n