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A Novel Small Molecule Inhibitor of Influenza A Viruses that Targets Polymerase Function and Indirectly Induces Interferon
Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate immune response and influenza viruses, like many v...
Autores principales: | Ortigoza, Mila Brum, Dibben, Oliver, Maamary, Jad, Martinez-Gil, Luis, Leyva-Grado, Victor H., Abreu, Pablo, Ayllon, Juan, Palese, Peter, Shaw, Megan L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343121/ https://www.ncbi.nlm.nih.gov/pubmed/22577360 http://dx.doi.org/10.1371/journal.ppat.1002668 |
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