Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation

Oxaliplatin-induced peripheral neurotoxicity (OPN) is commonly associated with peripheral hypersensitivity to cold sensations (CS) but the mechanism is unknown. We hypothesized that the transient receptor potential melastatin 8 (TRPM8), a putative cold and menthol receptor, contributes to oxaliplati...

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Detalles Bibliográficos
Autores principales: Kono, Toru, Satomi, Machiko, Suno, Manabu, Kimura, Norihisa, Yamazaki, Hirotaka, Furukawa, Hiroyuki, Matsubara, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343300/
https://www.ncbi.nlm.nih.gov/pubmed/22574275
http://dx.doi.org/10.1002/brb3.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343300/
https://www.ncbi.nlm.nih.gov/pubmed/22574275
http://dx.doi.org/10.1002/brb3.34

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