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Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation

Oxaliplatin-induced peripheral neurotoxicity (OPN) is commonly associated with peripheral hypersensitivity to cold sensations (CS) but the mechanism is unknown. We hypothesized that the transient receptor potential melastatin 8 (TRPM8), a putative cold and menthol receptor, contributes to oxaliplati...

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Detalles Bibliográficos
Autores principales:	Kono, Toru, Satomi, Machiko, Suno, Manabu, Kimura, Norihisa, Yamazaki, Hirotaka, Furukawa, Hiroyuki, Matsubara, Kazuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Inc 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343300/ https://www.ncbi.nlm.nih.gov/pubmed/22574275 http://dx.doi.org/10.1002/brb3.34

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