A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons

Microcephaly is a clinical characteristic for human nijmegen breakage syndrome (NBS, mutated in NBS1 gene), a chromosomal instability syndrome. However, the underlying molecular pathogenesis remains elusive. In the present study, we demonstrate that neuronal disruption of NBS (Nbn in mice) causes mi...

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Detalles Bibliográficos
Autores principales: Li, Rui, Yang, Yun-Gui, Gao, Yunzhou, Wang, Zhao-Qi, Tong, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343649/
https://www.ncbi.nlm.nih.gov/pubmed/22212482
http://dx.doi.org/10.1038/cr.2012.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343649/
https://www.ncbi.nlm.nih.gov/pubmed/22212482
http://dx.doi.org/10.1038/cr.2012.3

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