Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

11β-Hydroxysteroid dehydrogenase type1 (11βHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11βHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses wer...

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Detalles Bibliográficos
Autores principales: Sakkiah, Sugunadevi, Meganathan, Chandrasekaran, Sohn, Young-Sik, Namadevan, Sundaraganesan, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344271/
https://www.ncbi.nlm.nih.gov/pubmed/22606035
http://dx.doi.org/10.3390/ijms13045138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344271/
https://www.ncbi.nlm.nih.gov/pubmed/22606035
http://dx.doi.org/10.3390/ijms13045138

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