The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated strain of Mycobacterium bovis, is an approved vaccine. BCG sequesters in immature phagosomes of antigen presenting cells (APCs), which do not fu...

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Detalles Bibliográficos
Autores principales: Saikolappan, Sankaralingam, Estrella, Jaymie, Sasindran, Smitha J., Khan, Arshad, Armitige, Lisa Y., Jagannath, Chinnaswamy, Dhandayuthapani, Subramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344844/
https://www.ncbi.nlm.nih.gov/pubmed/22574140
http://dx.doi.org/10.1371/journal.pone.0036198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344844/
https://www.ncbi.nlm.nih.gov/pubmed/22574140
http://dx.doi.org/10.1371/journal.pone.0036198

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