A Novel Solid-Phase Site-Specific PEGylation Enhances the In Vitro and In Vivo Biostabilty of Recombinant Human Keratinocyte Growth Factor 1

Keratinocyte growth factor 1 (KGF-1) has proven useful in the treatment of pathologies associated with dermal adnexae, liver, lung, and the gastrointestinal tract diseases. However, poor stability and short plasma half-life of the protein have restricted its therapeutic applications. While it is pos...

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Detalles Bibliográficos
Autores principales: Huang, Zhifeng, Zhu, Guanghui, Sun, Chuanchuan, Zhang, Jingui, Zhang, Yi, Zhang, Youting, Ye, Chaohui, Wang, Xiaojie, Ilghari, Dariush, Li, Xiaokun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344868/
https://www.ncbi.nlm.nih.gov/pubmed/22574160
http://dx.doi.org/10.1371/journal.pone.0036423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344868/
https://www.ncbi.nlm.nih.gov/pubmed/22574160
http://dx.doi.org/10.1371/journal.pone.0036423

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