Transcriptional and Post-Transcriptional Regulation of SPAST, the Gene Most Frequently Mutated in Hereditary Spastic Paraplegia

Hereditary spastic paraplegias (HSPs) comprise a group of neurodegenerative disorders that are characterized by progressive spasticity of the lower extremities, due to axonal degeneration in the corticospinal motor tracts. HSPs are genetically heterogeneous and show autosomal dominant inheritance in...

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Detalles Bibliográficos
Autores principales: Henson, Brian J., Zhu, Wan, Hardaway, Kelsey, Wetzel, Jaime L., Stefan, Mihaela, Albers, Kathryn M., Nicholls, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344893/
https://www.ncbi.nlm.nih.gov/pubmed/22574173
http://dx.doi.org/10.1371/journal.pone.0036505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344893/
https://www.ncbi.nlm.nih.gov/pubmed/22574173
http://dx.doi.org/10.1371/journal.pone.0036505

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