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Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population

BACKGROUND: IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. METHODOLOGY/PRINCIPAL FINDINGS: Two functional polym...

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Detalles Bibliográficos
Autores principales: Grant, Audrey V., Araujo, Maria Ilma, Ponte, Eduardo Vieira, Oliveira, Ricardo Riccio, Gao, Peisong, Cruz, Alvaro A., Barnes, Kathleen C., Beaty, Terri H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345031/
https://www.ncbi.nlm.nih.gov/pubmed/22574126
http://dx.doi.org/10.1371/journal.pone.0035863