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Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis
Studies on hereditary pancreatitis have provided evidence in favor of central role for trypsin activity in the disease. Identification of genetic variants of trypsinogen linked the protease to the onset of pancreatitis, and biochemical characterization proposed an enzymatic gain of function as the i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345944/ https://www.ncbi.nlm.nih.gov/pubmed/22586407 http://dx.doi.org/10.3389/fphys.2012.00126 |