UU/UA Dinucleotide Frequency Reduction in Coding Regions Results in Increased mRNA Stability and Protein Expression

UU and UA dinucleotides are rare in mammalian genes and may offer natural selection against endoribonuclease-mediated mRNA decay. This study hypothesized that reducing UU and UA (UW) dinucleotides in the mRNA-coding sequence, including the codons and the dicodon boundaries, may promote resistance to...

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Detalles Bibliográficos
Autores principales: Al-Saif, Maher, Khabar, Khalid SA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345983/
https://www.ncbi.nlm.nih.gov/pubmed/22434136
http://dx.doi.org/10.1038/mt.2012.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345983/
https://www.ncbi.nlm.nih.gov/pubmed/22434136
http://dx.doi.org/10.1038/mt.2012.29

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