The Plausibility of RNA-Templated Peptides: Simultaneous RNA Affinity for Adjacent Peptide Side Chains

According to the RNA world hypothesis, coded peptide synthesis (translation) must have been first catalyzed by RNAs. Here, we show that small RNA sequences can simultaneously bind the dissimilar amino acids His and Phe in peptide linkage. We used in vitro counterselection/selection to isolate a pool...

Descripción completa

Detalles Bibliográficos
Autores principales: Turk-MacLeod, Rebecca M., Puthenvedu, Deepa, Majerfeld, Irene, Yarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346935/
https://www.ncbi.nlm.nih.gov/pubmed/22538927
http://dx.doi.org/10.1007/s00239-012-9501-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346935/
https://www.ncbi.nlm.nih.gov/pubmed/22538927
http://dx.doi.org/10.1007/s00239-012-9501-8

Ejemplares similares