A unifying model for mTORC1-mediated regulation of mRNA translation

The mTOR Complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses(1). mTORC1 regulates mRNA translation, but the overall translational program is poorly defined and no unifying model exists to explain how...

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Detalles Bibliográficos
Autores principales: Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347774/
https://www.ncbi.nlm.nih.gov/pubmed/22552098
http://dx.doi.org/10.1038/nature11083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347774/
https://www.ncbi.nlm.nih.gov/pubmed/22552098
http://dx.doi.org/10.1038/nature11083

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