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Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection
BACKGROUND: Prions, composed of a misfolded protein designated PrP(Sc), are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice succumb to disease significantly earlier than c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347999/ https://www.ncbi.nlm.nih.gov/pubmed/22436404 http://dx.doi.org/10.1186/1742-2094-9-58 |