NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA damage. Because the pathway may not be completely inhibited after blockade of PI3K itself, due to feedback through mammalian target of rapamycin (...

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Detalles Bibliográficos
Autores principales: Fokas, Emmanouil, Yoshimura, Michio, Prevo, Remko, Higgins, Geoff, Hackl, Wolfgang, Maira, Sauveur-Michel, Bernhard, Eric J, McKenna, W Gillies, Muschel, Ruth J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348043/
https://www.ncbi.nlm.nih.gov/pubmed/22452803
http://dx.doi.org/10.1186/1748-717X-7-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348043/
https://www.ncbi.nlm.nih.gov/pubmed/22452803
http://dx.doi.org/10.1186/1748-717X-7-48

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