B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

B cells have paradoxical roles in autoimmunity, exerting both pathogenic and protective effects. Pathogenesis may be antibody independent, as B cell depletion therapy (BCDT) leads to amelioration of disease irrespective of autoantibody ablation. However, the mechanisms of pathogenesis are poorly und...

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Detalles Bibliográficos
Autores principales: Barr, Tom A., Shen, Ping, Brown, Sheila, Lampropoulou, Vicky, Roch, Toralf, Lawrie, Sarah, Fan, Boli, O’Connor, Richard A., Anderton, Stephen M., Bar-Or, Amit, Fillatreau, Simon, Gray, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348102/
https://www.ncbi.nlm.nih.gov/pubmed/22547654
http://dx.doi.org/10.1084/jem.20111675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348102/
https://www.ncbi.nlm.nih.gov/pubmed/22547654
http://dx.doi.org/10.1084/jem.20111675

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