Pharmacogenetics Meets Metabolomics: Discovery of Tryptophan as a New Endogenous OCT2 Substrate Related to Metformin Disposition

Genetic polymorphisms of the organic cation transporter 2 (OCT2), encoded by SLC22A2, have been investigated in association with metformin disposition. A functional decrease in transport function has been shown to be associated with the OCT2 variants. Using metabolomics, our study aims at a comprehe...

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Detalles Bibliográficos
Autores principales: Song, Im-Sook, Lee, Do Yup, Shin, Min-Hye, Kim, Hyunmi, Ahn, Yun Gyong, Park, Inmyoung, Kim, Kyoung Heon, Kind, Tobias, Shin, Jae-Gook, Fiehn, Oliver, Liu, Kwang-Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348126/
https://www.ncbi.nlm.nih.gov/pubmed/22590580
http://dx.doi.org/10.1371/journal.pone.0036637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348126/
https://www.ncbi.nlm.nih.gov/pubmed/22590580
http://dx.doi.org/10.1371/journal.pone.0036637

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