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Integrated Analysis of Residue Coevolution and Protein Structure in ABC Transporters
Intraprotein side chain contacts can couple the evolutionary process of amino acid substitution at one position to that at another. This coupling, known as residue coevolution, may vary in strength. Conserved contacts thus not only define 3-dimensional protein structure, but also indicate which resi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348156/ https://www.ncbi.nlm.nih.gov/pubmed/22590562 http://dx.doi.org/10.1371/journal.pone.0036546 |