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Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+):Cl(−) exchanger
Active exchangers dissipate the gradient of one substrate to accumulate nutrients, export xenobiotics and maintain cellular homeostasis. Mechanistic studies suggested that all exchangers share two fundamental properties: substrate binding is antagonistic and coupling is maintained by preventing shut...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348462/ https://www.ncbi.nlm.nih.gov/pubmed/22484316 http://dx.doi.org/10.1038/nsmb.2277 |