Ordered Self-Assembly Mechanism of a Spherical Oncoprotein Oligomer Triggered by Zinc Removal and Stabilized by an Intrinsically Disordered Domain

BACKGROUND: Self-assembly is a common theme in proteins of unrelated sequences or functions. The human papillomavirus E7 oncoprotein is an extended dimer with an intrinsically disordered domain, that can form large spherical oligomers. These are the major species in the cytosol of HPV transformed an...

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Detalles Bibliográficos
Autores principales: Smal, Clara, Alonso, Leonardo G., Wetzler, Diana E., Heer, Angeles, de Prat Gay, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348928/
https://www.ncbi.nlm.nih.gov/pubmed/22590549
http://dx.doi.org/10.1371/journal.pone.0036457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348928/
https://www.ncbi.nlm.nih.gov/pubmed/22590549
http://dx.doi.org/10.1371/journal.pone.0036457

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