The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function

BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) mediates the transcriptional response to hypoxic stress, promoting tumour progression and survival. This study investigated the acute effects of the small-molecule HIF-pathway inhibitor NSC-134754. METHODS: Human PC-3LN5 prostate cancer cells were treat...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, L C J, Boult, J K R, Walker-Samuel, S, Chung, Y-L, Jamin, Y, Ashcroft, M, Robinson, S P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349173/
https://www.ncbi.nlm.nih.gov/pubmed/22498643
http://dx.doi.org/10.1038/bjc.2012.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349173/
https://www.ncbi.nlm.nih.gov/pubmed/22498643
http://dx.doi.org/10.1038/bjc.2012.131

Ejemplares similares