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UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

BACKGROUND: The proteins from the UBA-UBX family interact with ubiquitylated proteins via their UBA domain and with p97 via their UBX domain, thereby acting as substrate-binding adaptors for the p97 ATPase. In particular, human UBXN7 (also known as UBXD7) mediates p97 interaction with the transcript...

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Detalles Bibliográficos
Autores principales: Bandau, Susanne, Knebel, Axel, Gage, Zoe O, Wood, Nicola T, Alexandru, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349548/
https://www.ncbi.nlm.nih.gov/pubmed/22537386
http://dx.doi.org/10.1186/1741-7007-10-36