Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

BACKGROUND: Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identif...

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Detalles Bibliográficos
Autores principales: Surovtsova, Irina, Simus, Natalia, Hübner, Katrin, Sahle, Sven, Kummer, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349553/
https://www.ncbi.nlm.nih.gov/pubmed/22390191
http://dx.doi.org/10.1186/1752-0509-6-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349553/
https://www.ncbi.nlm.nih.gov/pubmed/22390191
http://dx.doi.org/10.1186/1752-0509-6-14

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