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Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice

BACKGROUND: Signaling studies in cell lines are hampered by non-physiological alterations obtained in vitro. Physiologic primary tumor cells from patients with leukemia require passaging through immune-compromised mice for amplification. The aim was to enable molecular work in patients' ALL cel...

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Detalles Bibliográficos
Autores principales:	Höfig, Ines, Ehrhardt, Harald, Jeremias, Irmela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349556/ https://www.ncbi.nlm.nih.gov/pubmed/22448764 http://dx.doi.org/10.1186/1478-811X-10-8

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